Lesson 5
2. Clonidine: Wallace
The clonidine study is very similar to the atenolol
study. Prospective, randomized, double blinded, placebo controlled,
clinical trial in 200 patients undergoing non-cardiac surgery
at the VA. Clonidine 0.2 mg PO as well as a Clonidine TTS-2 patch
(0.2 mg per day transcutaneous) were applied the night before
surgery (or placebo patch and pills). On the morning of surgery
another clonidine 0.2 mg PO tablet (or placebo) was administered.
The clonidine patch (or placebo patch) was continued for 4 days.
ECG, Holter, CPK-MB, Computerized blood pressure recordings, visual
analogue (VAS) pain scores, catecholamine levels, daily examinations
and long term follow-up were performed.
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Effect of clonidine on cardiovascular morbidity and mortality
after noncardiac surgery.
Anesthesiology 2004; 101: 284-93
Wallace, Galindez et al.
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Randomized, Placebo
Controlled, Double Blinded Clinical Trial in 200 patients
with or at risk for CAD undergoing non-cardiac surgery. |
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Clonidine 0.2 mg
po night before, 0.2 mg po day of, and 0.2 mg TTS-2 patch
for 4 days. Vs placebo pills and patch |
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ECG, Holter ECG,
CPK-MB, Computerized BP recording, VAS pain scores, catecholamines,
H&P |
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Long Term Follow-up
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