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The Beta Blocker and Clonidine Protocol

Lesson 5
Clonidine

7. Clonidine: Stuhmeier et al.

Small, oral dose of clonidine reduces the incidence of intraoperative myocardial ischemia in patients having vascular surgery.
Stuhmeier KD, Mainzer B, Cierpka J, Sandmann W, Tarnow J.
Anesthesiology. 1996 Oct;85(4):706-12

Am I the first guy to find that clonidine is good for patients at risk for cardiac risk? No. Stuhmeier et. al. (Anesthesiology. 1996 Oct;85(4):706-12) found that clonidine reduced the incidence of myocardial ischemia. I am thinking of changing my name to Et Al so that I will have a longer CV. Unfortunately, if I did, clearing security to get on an airplanes would be harder.

Stuhmeier et al., Anesthesiology. 1996 Oct;85(4):706-12

bullet A randomized double-blind study design was used in 297 patients scheduled to have elective vascular surgical procedures to evaluate the effects of 2 micrograms/kg-1 oral clonidine (n = 145) or placebo (n = 152) on the incidence of perioperative myocardial ischemic episodes, myocardial infarction, and cardiac death.
bullet Administration of clonidine reduced the incidence of perioperative myocardial ischemic episodes from 39% (59 of 152) to 24% (35 of 145) (P < 0.01).
bullet Oral clonidine, given prophylactically, can reduce the incidence of perioperative myocardial ischemic episodes without affecting hemodynamic stability in patients with suspected or documented coronary artery disease
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