8. More Dennis Mangano

Moreover, if you follow those patients after surgery. A single one minute episode of myocardial ischemia increases the risk of 2 year mortality (death) 2 fold.

Mangano et. al. JAMA 1992

	Prospective cohort study of long-term (2-year) cardiac prognosis of high-risk patients undergoing non-cardiac surgery
	Determine the predictors of long-term adverse cardiac outcome.
	Historical, clinical, and laboratory data were collected during the in-hospital period, and at 6 months, 1 year, and 2 years following surgery.
	Cardiac death, myocardial infarction, unstable angina, progressive angina requiring coronary artery bypass graft surgery or coronary angioplasty, and new unstable angina requiring hospitalization.
	11% had major cardiovascular complications during a 728-day (median) follow-up period
	24 cardiac death; 11 nonfatal myocardial infarction; 6 progressive angina requiring coronary artery bypass graft surgery or coronary angioplasty; 6 new unstable angina requiring hospitalization.

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